Opportunity Information: Apply for RFA AA 20 009
The Alcohol-HIV/AIDS Program Project Comorbidities, Coinfections, and Complications Research: Intervention and Cross-Cutting Foundational Research (P01 Clinical Trial Optional) funding opportunity (RFA AA-20-009) is a discretionary grant program from the U.S. Department of Health and Human Services through the National Institutes of Health. It uses the P01 "Program Project" mechanism, which is designed for coordinated, multi-project efforts where several related research projects are intentionally organized around a central theme and supported by shared resources. The scientific focus is on alcohol use disorders in the context of HIV, specifically research that can be translated into practical interventions aimed at reducing HIV infection and transmission among people with alcohol use disorders, while also addressing the broader set of comorbidities, coinfections, and complications that commonly occur alongside HIV and problematic alcohol use.
At the core of the announcement is an expectation that applicants will propose research that moves beyond basic association studies and points toward intervention-ready outcomes. In practice, that means developing, testing, optimizing, or otherwise advancing strategies that could realistically be implemented in clinical, community, or public health settings to lower HIV risk, reduce onward transmission, or improve HIV-related health outcomes in populations affected by alcohol use disorders. Because alcohol use can influence sexual risk behavior, medication adherence, engagement in care, immune function, and liver health, this FOA centers on work that recognizes alcohol as a major, modifiable driver of HIV vulnerability and HIV disease progression, and it encourages research that can inform targeted, evidence-based solutions.
The opportunity explicitly highlights "comorbidities, coinfections, and complications" as key areas of concern. This framing reflects the reality that many people living with HIV who also have alcohol use disorders face overlapping medical and behavioral health burdens, such as mental health disorders, substance use beyond alcohol, metabolic and cardiovascular issues, and infectious diseases that may complicate HIV care. Coinfections and organ-system complications are particularly relevant where alcohol contributes to inflammation, liver disease, and other physiological pathways that can worsen outcomes, increase treatment complexity, or impede consistent HIV prevention and care. The FOA also signals interest in "cross-cutting foundational research," meaning foundational work that supports or accelerates intervention development across projects, such as common measurement approaches, mechanistic studies that clarify how alcohol affects HIV-related outcomes, or platform resources that multiple projects can use to strengthen translation.
The "Clinical Trial Optional" designation indicates that applications may include clinical trials, but they are not required. This gives applicants flexibility to propose the most appropriate study designs for their intervention and translational goals, ranging from preclinical or early-stage translational work through pragmatic or effectiveness-oriented studies, depending on the maturity of the intervention and the evidence base. In a P01 structure, different components can often operate at different points along the translational spectrum, for example pairing foundational work that clarifies mechanisms with intervention studies that test strategies in relevant settings or populations.
In terms of funding and scale, the award ceiling listed is $1,000,000, and the agency anticipated making about 8 awards under this announcement. The opportunity falls under the health funding activity category and is associated with CFDA number 93.273. The FOA was created on June 3, 2020, with an original closing date of November 17, 2020, which places it in a specific funding cycle, though the summary details remain useful for understanding the program priorities and the kind of projects NIH sought to support through this call.
Eligibility is broad and includes a wide range of organizations capable of conducting or supporting health research. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other entities as further clarified in the FOA. This wide eligibility reflects the interdisciplinary and multi-sector nature of alcohol-HIV intervention research, which often benefits from partnerships among academic researchers, healthcare systems, community organizations, and public agencies.
Overall, this FOA supports integrated, team-based program projects that aim to produce actionable knowledge and intervention pathways to reduce HIV infection and transmission in people with alcohol use disorders, while also addressing the intertwined medical and public health challenges that arise from comorbidities, coinfections, and complications. The emphasis on translation, coupled with the flexibility to include clinical trials, is meant to accelerate progress toward interventions that can make a measurable difference in real-world HIV prevention and care for populations where alcohol use significantly elevates risk and worsens outcomes.Apply for RFA AA 20 009
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Alcohol-HIV/AIDS Program Project Comorbidities, Coinfections, and Complications Research: Intervention and Cross-Cutting Foundational Research (P01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
- This funding opportunity was created on Jun 03, 2020.
- Applicants must submit their applications by Nov 17, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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