Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional) | PAR 22 093

Opportunity Information: Apply for PAR 22 093

The National Institutes of Health (NIH) is offering this discretionary grant opportunity under Funding Opportunity Announcement (FOA) PAR-22-093, titled "Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)." The main aim is to support investigator-initiated research projects that address timely, high-priority scientific questions in Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRD). Rather than locking applicants into a single narrow research theme, the FOA is designed to stay flexible: NIH plans to announce the specific high-priority topics through a series of follow-up Notices released after the FOA, allowing the program to respond to emerging needs and fast-moving developments in the field.

This opportunity uses the R01 mechanism, which is NIH's standard, large-scale research project grant intended for well-developed studies with clearly defined aims. The "Clinical Trial Optional" designation means applicants may propose either non-clinical-trial research (for example, basic, translational, computational, or observational studies that do not meet NIH's definition of a clinical trial) or a project that does include a clinical trial, if a trial is scientifically justified and fits NIH requirements for trial oversight and reporting. In practical terms, this gives applicants room to propose anything from laboratory and animal work that informs dementia mechanisms, to human studies that test interventions, biomarkers, care strategies, or other clinical approaches, as long as the project aligns with current AD/ADRD priorities described in the subsequent Notices.

Eligibility is broad and intentionally inclusive. In addition to the typical categories of applicants such as state, county, city or township governments, special district governments, independent school districts, and public housing authorities, the FOA is open to many kinds of academic, nonprofit, and private-sector organizations. Eligible entities include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education), for-profit organizations (other than small businesses), and small businesses. It also includes Native American tribal governments that are federally recognized, as well as Native American tribal organizations and tribal governments that are not federally recognized. NIH also explicitly highlights additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Faith-based or community-based organizations are included, as are eligible federal agencies, regional organizations, and applicants located in a U.S. territory or possession. Non-domestic (non-U.S.) entities (foreign organizations) are also eligible, signaling that NIH is willing to fund strong dementia research wherever the most appropriate expertise and study populations exist, subject to NIH policies.

The funding activity category is Health, and the listing references CFDA numbers 93.853 and 93.866, which correspond to NIH program areas associated with aging, neurological disorders, and related biomedical research portfolios. The FOA record indicates an original closing date of 2024-11-12, meaning applicants should plan around that deadline and also monitor NIH updates and Notices tied to PAR-22-093. The award ceiling is not specified in the provided data, and the expected number of awards is not listed, which often means budgets and award volumes will depend on project scope, NIH institute priorities, and available appropriations at the time of award decisions.

Overall, this FOA is best understood as a standing invitation for robust R01 applications that tackle pressing AD/ADRD questions as they are defined over time by NIH through accompanying Notices. A competitive application would typically be expected to make a clear case for significance to AD/ADRD, show strong scientific rigor and feasibility, and explicitly connect the proposed work to the current high-priority topics once they are published. Applicants also need to decide early whether their work meets the NIH definition of a clinical trial, since that affects application structure, required documentation, and compliance obligations.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853, 93.866.
• This funding opportunity was created on 2021-12-22.
• Applicants must submit their applications by 2024-11-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 22 093

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