NIAID Investigator Initiated Program Project Applications (P01) | PAR 16 413

Opportunity Information: Apply for PAR 16 413

The NIAID Investigator Initiated Program Project Applications (P01) opportunity (Funding Opportunity Number PAR-16-413) is a National Institutes of Health discretionary grant program that supports large, coordinated research efforts built around a shared scientific theme. It is designed for investigator-initiated program projects, meaning applicants propose their own integrated research agenda rather than responding to a narrowly defined topic area. The core requirement is that each P01 application must include at least two scientifically related research projects that are clearly connected by a common central theme, focus, and/or overall objective, with the expectation that the projects collectively deliver more impact together than they would as separate, independent studies.

Scientifically, the FOA is broad but firmly aligned with the mission of the National Institute of Allergy and Infectious Diseases (NIAID). Proposed program projects may address the biology of microbes and how they cause disease, including work involving HIV, as well as studies of pathogenesis and host responses to infection. It also welcomes research on the immune system itself, including normal immune development and function, and what happens when immunity goes wrong, such as autoimmunity, immunodeficiency, allergy, asthma, and transplant rejection. In addition to fundamental and mechanistic work, the FOA explicitly encourages translational research aimed at developing vaccines, therapeutics, and diagnostics for preventing and treating infectious diseases and immune-mediated or allergic conditions. In practice, this means applicants can propose programs that move from basic discovery through preclinical development and, where appropriate, toward clinically relevant tools, as long as the overall program remains cohesive and well-justified as a multi-project effort.

Eligibility spans a wide range of organization types. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public housing authorities and Indian housing authorities; and federally recognized Native American tribal governments, as well as tribal organizations that are not federally recognized. Higher education institutions are eligible across both public/state-controlled and private categories. The FOA also allows nonprofit organizations (both those with and without 501(c)(3) IRS status), for-profit organizations (other than small businesses), and small businesses, along with additional eligible entities captured under the general "other" category listed in the source data. The announcement also highlights specific categories of eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISI), as well as faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. Together, these provisions indicate NIAID is open to a broad range of institutional settings capable of supporting multi-project research programs.

At the same time, the FOA places clear limits on non-U.S. applicants. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply as the primary applicant organization. Non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed under the NIH Grants Policy Statement definition, which generally means a U.S.-based applicant may include certain work performed outside the United States when it is well-justified and appropriately structured as a foreign component rather than a foreign applicant.

Administratively, this is an NIH grant mechanism under the health activity category, with CFDA numbers 93.855 and 93.856. The opportunity was created on 2016-08-18, and the listed original closing date in the provided data is 2020-01-07. The source information provided does not specify an award ceiling or the expected number of awards, which typically means applicants should consult the full FOA and related NIH documentation for current budget expectations, limits, and application cycle details. Overall, the program is best understood as a vehicle for investigators to propose an integrated set of complementary projects that, together, tackle significant questions in infectious disease and immunology and/or advance the development of countermeasures like vaccines, treatments, and diagnostics.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIAID Investigator Initiated Program Project Applications (P01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855, 93.856.
• This funding opportunity was created on 2016-08-18.
• Applicants must submit their applications by 2020-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 16 413

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