Opportunity Information: Apply for CDC RFA PS22 2203
The CDC, through the Department of Health and Human Services and its National Center for HIV, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), offered this FY 2022 cooperative agreement (Funding Opportunity Number CDC RFA PS22-2203; CFDA 93.939) to support community-based organizations in building and running comprehensive, high-impact HIV prevention programs. The focus is on reducing persistent HIV-related disparities and improving health outcomes for two priority populations: young men of color who have sex with men and young transgender persons of color. In this announcement, "young" and "youth" are defined broadly as ages 13 through 34, which signals an emphasis on both adolescents and young adults rather than only minors or only college-age groups.
The opportunity is organized into two service categories that applicants would align with based on who they intend to serve. Category A centers HIV prevention services for young men of color who have sex with men (YMSM of color), while Category B centers HIV prevention services for young transgender persons of color (YTG persons of color). In both categories, services are intended to reach not only the priority group but also their partners, regardless of the partners' age, gender, or race/ethnicity. That design reflects how HIV prevention works in practice: transmission risk and prevention opportunities often sit within sexual and social networks, so the programs are expected to engage beyond a single demographic label when it improves prevention impact.
A key theme of the grant is that community-based organizations are positioned to extend and strengthen what health departments do, especially by tailoring outreach and services to communities that may not be fully reached through traditional public health channels. The CDC frames CBOs as essential partners that can optimize prevention services across public, private, and community systems, helping create smoother pathways from testing to prevention to care. Practically, this includes identifying people with undiagnosed HIV through effective testing and linkage strategies, increasing referrals and access to biomedical prevention tools like pre-exposure prophylaxis (PrEP) and non-occupational post-exposure prophylaxis (nPEP), and supporting earlier entry into HIV medical care for those who test positive. It also emphasizes keeping people engaged consistently in care, since continuity is closely tied to viral suppression and reduced morbidity and mortality.
The overall purpose is to implement "comprehensive high-impact" HIV prevention programs, meaning the work is expected to be more than a single intervention or a limited outreach effort. The intent is to deliver integrated prevention that measurably improves outcomes along the HIV prevention and care continuum, while directly addressing inequities that drive disproportionate HIV burden among YMSM of color and YTG persons of color. The announcement also makes explicit that programs should support health equity by acknowledging and responding to social determinants of health and syndemics (overlapping, reinforcing challenges like stigma, mental health needs, substance use, housing instability, and violence) that can affect HIV risk, testing frequency, PrEP uptake, and retention in care.
Strategically, this funding is positioned as part of larger national efforts. It aligns with the HIV National Strategic Plan for 2021-2025 and CDC's Division of HIV Prevention strategic direction, and it complements the federal Ending the HIV Epidemic in the United States initiative. The announcement ties its expected impact to the national targets of reducing new HIV infections by 75 percent by 2025 and by 90 percent by 2030, indicating the CDC is looking for programs that contribute to measurable, population-level progress rather than isolated activities.
Administratively, this was released as a discretionary cooperative agreement, which typically means recipients should expect substantial federal involvement beyond a simple pass-through grant (for example, technical assistance, program guidance, and collaborative planning with CDC project officers). The posting lists an expected 30 awards. It was created on September 21, 2021, with an application deadline of November 19, 2021 (electronically submitted applications due by 11:59 pm ET). The eligible applicant field is broadly described and includes "Others," with additional eligibility details referenced as being in the full announcement text. The award ceiling is listed as 0 in the source data, which usually indicates the ceiling was not specified in that particular summary field and would need to be confirmed in the full funding announcement and budget guidance.Apply for CDC RFA PS22 2203
- The Department of Health and Human Services, Centers for Disease Control - NCHHSTP in the health sector is offering a public funding opportunity titled "Comprehensive High-Impact HIV Prevention Programs for Young Men of Color Who Have Sex with Men and Young Transgender Persons of Color" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.939.
- This funding opportunity was created on Sep 21, 2021.
- Applicants must submit their applications by Nov 19, 2021 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 30 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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